Welcome to the It's a Man's World guide at TV Tome.
This weekly hour-long series centered on four young men who live in a houseboat moored at an Ohio River town named Cordella.  The main characters were college student Wes Macauley and his younger brother Howie, recently orphaned by an auto accident, Tom-Tom DeWitt, another college student, and Vern Hodges, a foot-loose type who moves in to join them.