Each episode follows two extraordinary individuals whose anatomy has transformed their lives. In the first episode about bones: 9-year-old Jake Grys might break a rib just by coughing and has broken practically every bone in his body; 28-year-old Holly Pullano has her muscles and tendons turn to bone after the slightest impact. In the second episode about blood: 12-year-old Son Pham has abnormal blood vessels, causing a huge balloon-like mass that has taken over his face; 16-year-old Michael Politzer has a vascular system that has mangled and reshaped his organs, causing bone and tissue overgrowth. (Source: National Geographic Channel)